Polynucleotide
Not sure where to start?
Book a free OBSERV skin analysis and we'll recommend the right treatment for you.
Polynucleotide Treatment
Polynucleotide Therapy: Repair. Renew. Rebuild.
From £250
Polynucleotide treatment uses naturally derived DNA fragments to stimulate the skin’s own regenerative processes, encouraging new collagen, improved elasticity and better hydration from within. It’s especially popular for delicate, thin-skinned areas such as under the eyes.
Unlike traditional fillers, it works by improving the quality of the skin itself rather than adding volume, making it a popular choice for tired, crepey or dehydrated skin. A course of sessions is usually recommended for optimal, long-lasting results.
BOOK A CONSULTATION
Meet a MedSkin Studios expert for your free consultation.
FREE
BUY A PACKAGE
Pay per session, or save when you purchase a package.
FROM £250
What Is Polynucleotide Treatment?
Polynucleotides are chains of purified DNA fragments that act as a powerful signal to your own skin cells. Rather than adding volume like a filler, they work at cell level to calm inflammation, draw in water and stimulate fibroblasts — the cells responsible for producing collagen and elastin.
The result is a genuine improvement in skin quality rather than a change in shape: firmer, better hydrated, more resilient skin with improved tone and texture. At MedSkin Studios polynucleotides are especially popular for the delicate skin under the eyes, and for anyone whose main concern is thinning, crepiness or dullness rather than lost volume.
Polynucleotide treatment works in three stages:
- 1. Signalling: Once injected, the polynucleotide chains bind water and send repair signals to the surrounding skin cells.
- 2. Regeneration: Fibroblast activity increases, inflammation is calmed and new collagen and elastin production begins.
- 3. Remodelling: Over the following weeks the skin becomes visibly firmer, thicker and better hydrated, with results continuing to build after each session.
Targeted Treatment Areas
Polynucleotides can be used wherever skin quality, thinning or dehydration is the main concern:
- Under-Eyes: Dark circles, crepey texture and thin, tired-looking skin across the tear trough.
- Face & Neck: Overall laxity, dullness, fine lines, acne scarring and reactive or rosacea-prone skin.
- Body & Scalp: Décolletage, backs of the hands, stretch marks, and the scalp to support hair thickness.
Key Benefits of Polynucleotide Treatment
- Improves Skin Quality: Targets the health, thickness and resilience of the skin rather than simply adding volume.
- Excellent Under-Eyes: One of the few treatments that safely improves thin, crepey and darkened under-eye skin.
- Calms Inflammation: Anti-inflammatory and antioxidant action makes it well suited to reactive, rosacea-prone and acne-prone skin.
- Deep Hydration: Holds water within the tissue, restoring plumpness and bounce over time.
- Stimulates Collagen: Activates your own fibroblasts, so improvements continue developing for months after your course.
- Highly Compatible: Works well alongside anti-wrinkle injections, filler, microneedling and laser treatments.
What to Expect During Your Treatment
- Consultation: Your skin is assessed and your medical history reviewed to confirm polynucleotides are the right choice and to plan your course.
- Preparation: The area is cleansed and numbing cream is applied, which is particularly important for under-eye treatment.
- Treatment: A series of small, superficial injections deposit the product just beneath the skin. Each session takes around twenty to thirty minutes.
- Aftercare: Small bumps and mild swelling settle within a day or two. Avoid make-up, exercise and heat for twenty-four hours.
A course of two to three sessions spaced two to four weeks apart is usually recommended, with results continuing to improve for several months afterwards. Most clients then maintain their results with a single top-up session every six to nine months.
Frequently Asked Questions
Are polynucleotide injections painful?
Mildly uncomfortable rather than painful. Numbing cream is applied first and the injections are very superficial, so most clients tolerate the treatment easily — including under the eyes.
What is the downtime after treatment?
Minimal. You may have small raised bumps, slight redness or mild swelling for twenty-four to forty-eight hours, and occasionally a small bruise. Most clients return to normal activities straight away.
How many sessions will I need?
Usually two to three sessions spaced two to four weeks apart, depending on your starting point. A maintenance session every six to nine months keeps the results going.
When will I see results?
Skin often feels better hydrated within a week, but the real changes in firmness and texture appear from four to six weeks and continue building for up to three months after your final session.
How is this different from dermal filler?
Filler adds volume and structure. Polynucleotides add no volume at all — they improve the quality, thickness and hydration of the skin itself, which is why they suit thin under-eye skin so well.
Healthier Skin, Regenerated From Within.
Polynucleotide treatment works with your own biology to improve the quality and resilience of your skin — a regenerative approach rather than a cosmetic filler.
BOOK A CONSULTATION
Meet a MedSkin Studios expert for your free consultation.
FREE
Before & After Results
Real client results shared with signed client consent.
BEFORE
AFTER
Related Treatments
Most Popular
Anti-Wrinkle Treatment
A quick injectable treatment that relaxes targeted facial muscles to soften fine lines and wrinkles, especially around the forehead, eyes and brows. Results develop over two weeks and last three to four months.
Dermal Filler
Hyaluronic acid-based injections that restore lost volume and add subtle definition to the cheeks, lips, jawline and other areas. Results are natural-looking, immediate, and typically last six to eighteen months.
Profhilo
An injectable bio-remodelling treatment that delivers pure hyaluronic acid to deeply hydrate the skin and boost elasticity. Improves skin laxity, tone and radiance without adding volume.
Most Popular
Ready to Start Your Skin Journey?
Book a consultation with our aesthetic experts to discuss a tailored treatment plan for your skin.
